Onset and progression of various age-related diseases

1. AGRN is associated with onset and progression of various age-related diseases.

   “Agrin exhibits a distinct ''double-edged sword'' characteristic across different disease stages or tissue contexts-exerting protective effects in some scenarios while promoting pathological progression in others.”

   Reviewreview of context-dependent mechanisms

   Agrin at the crossroads of aging: A pleiotropic regulator in age-related diseases

   Pharmacological research·5 Feb 2026

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