5 papers2 findings
Clonal hematopoiesis of indeterminate potential
upin humans1
Clonal hematopoiesis of indeterminate potential raises the risk of neoplasia in humans (0.5% to 1% per year).
“The rate of development of overt neoplasia in patients with clonal hematopoiesis of indeterminate potential (CHIP), as currently defined, is 0.5% to 1% per year.”
Reviewin patients with CHIP
Clinical consequences of clonal hematopoiesis of indeterminate potential
Blood advances27 Nov 2018
Werner syndrome
upin humans1
Werner syndrome raises the risk of neoplasia in humans.
“Cancer risk defined by SIRs was significantly elevated in Japan-resident WS patients for the six most frequent neoplasms except leukemia”
Humans
Spectrum and risk of neoplasia in Werner syndrome: a systematic review
PloS one1 Apr 2013
The Netherlands Cancer Institute
1 trialPhase 21,550 people
National Cancer InstituteUS$2.7m
National Cancer InstituteIcahn School of Medicine at Mount SinaiUS$1.1m2021–2027
National Cancer InstituteWashington UniversityUS$554k2020–2027
Mutant blood cells induced stromal senescence, while depleting senescent non-haematopoietic cells reduced clonal burden and delayed progression to myeloid neoplasia in…Mutant blood cells induced stromal senescence, while depleting senescent non-haematopoietic cells reduced clonal burden and delayed progression to myeloid neoplasia in mice.