An observational study spanning 18,476 people in China linked an aging measure developed in a healthy group to chronic disease and death risk.An observational study spanning 18,476 people in China linked an aging measure developed in a healthy group to chronic disease and death risk.
Cohort study of healthy-cohort participants in China, 2019 to 2025Biomarkers
Limit: The abstract omits risk-increase sizes, leaving the strength of the associations unclear
Across 985,026 participants, disease-causing DNA expansions occurred in about 1 in 1,527, compared with earlier disease prevalence estimates of 1 in 3,000–8,000.Across 985,026 participants, disease-causing DNA expansions occurred in about 1 in 1,527, compared with earlier disease prevalence estimates of 1 in 3,000–8,000.
Genetic association study of 985,026 peoplePopulations
The mortality hazard ratio was 2.03 for participants with under 5 nanograms per millilitre of vitamin D compared with those with at least 20.The mortality hazard ratio was 2.03 for participants with under 5 nanograms per millilitre of vitamin D compared with those with at least 20.
Mendelian randomization across more than 265,000 UK Biobank and FinnGen participants linked a higher CALLY score to reduced dementia risk but increased sleep disorder…Mendelian randomization across more than 265,000 UK Biobank and FinnGen participants linked a higher CALLY score to reduced dementia risk but increased sleep disorder risk.