What does the research say about Malignant progression?

Malignant progression

There is 1 paper on malignant progression in aging research: 1 observational study in people. The newest story, Oct 7, 2026: “Blood-cell mutation patterns linked to cancer progression”.

Disease

1 paper studies it41 more mention it2 findings

3 new papers in 30 daysSee all 42

“mutations driving faster clonal growth carry a higher risk of malignant progression”

The longitudinal dynamics and natural history of clonal haematopoiesisNature2022doi:10.1038/s41586-022-04785-z

Humans1

Associations

Complex karyotype

upin humans1

1 study

Malignant progression is associated with complex karyotype in humans.
“Malignant progression was accompanied by a complex karyotype, recurrent chromosome 5, 7, and 12p losses enriched in erythroid progenitors”
Humanserythroid progenitors
Intense TP53 pathway selection drives clonal evolution from bone marrow failure to leukemia in ERCC6L2 disease
medRxivSep 17, 2026Preprint

Latest

21 papers in 12 months

NatureJun 2

The longitudinal dynamics and natural history of clonal haematopoiesis

Cohort study of 385 peopleBlood and immune system

Paper

Nucleic Acids ResearchOct 30

Atlas maps sex differences across human cancer cells

The database combines data from 6,764 patient samples, covering 18 cancer types and more than 25.8 million single cells.The database combines data from 6,764 patient samples, covering 18 cancer types and more than 25.8 million single cells.

Computational studyAI & data

Paper

Cancer Epidemiology, Biomarkers & PreventionOct 8

INCREASED PREVALENCE OF PANCREATIC CYSTS IN NONSECRETOR (FUT2 NULL) INDIVIDUALS UNDER PANCREATIC SURVEILLANCE

Genetic association study of 1,865 peoplePancreatic ductal adenocarcinoma

Paper

HemaSphereOct 7

Blood-cell mutation patterns linked to cancer progression

A yearly rise of at least 7.5% in mutated gene copies’ share best predicted cancer progression among patients with unexplained low counts of certain white blood cells.A yearly rise of at least 7.5% in mutated gene copies’ share best predicted cancer progression among patients with unexplained low counts of certain white blood cells.

Cohort study of 256 peopleCancer

Paper

Gut PathogensSep 26