Clonal growth rate

There is 1 paper on clonal growth rate in aging research: 1 observational study in people. The newest story, Oct 28, 2026: “Vitamin C did not slow growth of mutated blood-cell groups”.

Biomarker

1 paper studies it2 more mention it2 findings

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“mutations driving faster clonal growth carry a higher risk of malignant progression”
The longitudinal dynamics and natural history of clonal haematopoiesisNature2022doi:10.1038/s41586-022-04785-z
  • Humans1

Upstream

1

SRSF2P95H

upin humans1

1 study
  1. SRSF2P95H is linked with higher clonal growth rate in humans (more than 50% per year).

    “with different mutations driving substantially different growth rates, ranging from 5% (DNMT3A and TP53) to more than 50% per year (SRSF2P95H)”

    Humans

    The longitudinal dynamics and natural history of clonal haematopoiesis

    Nature

More on SRSF2P95H

Associations

1

Malignant progression

upin humans1

1 study
  1. Clonal growth rate is linked with a higher risk of malignant progression in humans (mutations driving faster clonal growth).

    “mutations driving faster clonal growth carry a higher risk of malignant progression”

    Humansmutations driving faster clonal growth

    The longitudinal dynamics and natural history of clonal haematopoiesis

    Nature

More on Malignant progression

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Cancer

Vitamin C did not slow growth of mutated blood-cell groups

Median growth of mutated blood-cell groups was 0.016 per year lower with vitamin C than placebo, but the results were consistent with no difference.Median growth of mutated blood-cell groups was 0.016 per year lower with vitamin C than placebo, but the results were consistent with no difference.

Randomized trialVitamin C