Male sexual dysfunction

1. Statins are associated with male sexual dysfunction in humans (Spontaneous adverse event reports identifying statins as the primary suspected drug) (28 high-risk ADR signals).

   “Totally, 28 high-risk ADR signals for male sexual dysfunction were identified”

   HumansSpontaneous adverse event reports identifying statins as the primary suspected drugmalesn = 2,173

   Adverse drug reaction signals of statin-induced male sexual dysfunction: Mining and analysis based on the FDA Adverse Event Reporting System

   Zhonghua nan ke xue = National journal of andrology·Feb 1, 2026

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1. GLP-1 receptor agonists are associated with male sexual dysfunction in humans (spontaneous adverse event reports in FAERS, disproportionality analysis) (ROR 0.41 (95% CI 0.36-0.48)).

   “low ROR (0.41, 95% Confidence interval (CI): 0.36-0.48), PRR (0.41, 95% CI: 0.36-0.48), and RRR (0.42, 95% CI: 0.36-0.48) suggest a weak association”

   Humansspontaneous adverse event reports in FAERS, disproportionality analysismalesn = 182

   Male sexual dysfunction associated with GLP-1 receptor agonists: a cross-sectional analysis of FAERS data

   International journal of impotence research·Apr 16, 2025

More on GLP-1 receptor agonists

1. Male sexual dysfunction is associated with sexual inactivity in humans (cohabiting Brazilian couples) (OR 4.51, 95% CI 1.60-12.70).

   “male sexual dysfunction (OR: 4.51, 95% CI: 1.60-12.70, P = 0.004)”

   Humanscohabiting Brazilian couplesn = 266

   Female and male factors that impact on frequency of sexual intercourse in aging couples: a cross-sectional study

   Menopause (New York, N.Y.)·Aug 27, 2024