Lymphoblastic leukemia

1 paper1 finding

Animals1

Associations

1

GATA2

upin mice1

1 study

GATA2 raises the risk of lymphoblastic leukemia in mice.
“our models showed that GATA2 haploinsufficiency leads to B lymphopenia, monocytopenia, lethal bone marrow failure (BMF), myelodysplasia, and lymphoblastic leukemia.”
Animalsserial and limiting donor-cell transplantation of 14-15 months GATA2 haploinsufficient cells
Hematological phenotypes in GATA2 deficiency syndrome arise from aging, maladaptation to proliferation, and somatic events
Blood advances27 Mar 2025

Trial sponsors

Southern Medical University 2025 University-Level Student Innovation and Entrepreneurship Training Program Project
3 trialsPhase 2/3270 people
M.D. Anderson Cancer Center
2 trialsPhase 2122 people
University of Chicago
2 trialsPhase 240 people
Children's Hospital of Philadelphia
1 trialPhase 280 people
Massachusetts General Hospital
1 trialPhase 232 people
Tanja Andrea Gruber
1 trialPhase 1/290 people
Abramson Cancer Center at Penn Medicine
1 trialPhase 1/24 people
Emory University
1 trialPhase 18 people

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