Lower extremity arterial disease

Disease

1 paper1 finding

  • Humans1

Associations

1

SGLT2 inhibitors

upin humans1HR 1.53

1 study
  1. SGLT2 inhibitors raise the risk of lower extremity arterial disease in humans (HR: 1.53).

    “Compared to metformin, SGLT2is showed a higher HR for severe LEAD, especially with diastolic blood pressure (dBP) below 80 mmHg (HR: 1.53)”

    Humansdiastolic blood pressure below 80 mmHgthree-year

    Risk of Severe Lower Extremity Arterial Disease in Elderly Japanese Patients with Type 2 Diabetes—A Propensity Score-Matched Model Analysis of Sodium–Glucose Cotransporter 2 Inhibitors vs. Metformin

    ADA Scientific Sessions 2025 abstract13 Jun 2025

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