Late-life depression with late onset

1. Late-life depression with late onset impairs fluid intelligence in humans.

   “The LLD-LO group performed worse than LLD-EO on fluid intelligence.”

   Humanscompared with LLD-EOn = 75,064

   Late-onset depression predicts cognitive impairment and subsequent dementia among older adults with major depressive disorder: findings from UK Biobank and primary care linked data

   BJPsych open·1 Mar 2026

1. Late-life depression with late onset impairs cognitive function in humans.

   “LLD-LO group (n = 4858) showed significantly worse cognitive performance than healthy controls, particularly on fluid intelligence and visuospatial memory.”

   Humansn = 75,064

   Late-onset depression predicts cognitive impairment and subsequent dementia among older adults with major depressive disorder: findings from UK Biobank and primary care linked data

   BJPsych open·1 Mar 2026

1. Late-life depression with late onset raises the risk of dementia in humans (hazard ratio 1.42-1.52).

   “During follow-up, LLD-LO was associated with a higher risk of incident dementia (hazard ratio 1.42-1.52) across all adjusted models.”

   Humansn = 75,064

   Late-onset depression predicts cognitive impairment and subsequent dementia among older adults with major depressive disorder: findings from UK Biobank and primary care linked data

   BJPsych open·1 Mar 2026

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