Lactic acidosis

1. HIF1A decreases lactic acidosis in mice.

   “liver-specific activation of HIF1α improved age-associated impairment in lactate tolerance, lactic acidosis in skeletal muscle, and sarcopenia.”

   Animalsliver-specific activation in aged miceskeletal muscle

   Impaired liver-muscle lactate metabolism causes sarcopenia via lactic acidosis in skeletal muscle in mice

   Science advances·4 Sep 2026

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