2 papers2 findings
CD38 inhibitors
downin animals1
CD38 inhibitors protect against intrauterine growth restriction.
“rescues intrauterine growth restriction”
Animals
Macrophage CD38 drives age-related placental senescence by depleting NAD+
Nature communications27 Aug 2026
NAD+ precursors
downin animals1
NAD+ precursors protect against intrauterine growth restriction.
“treatment with NAD+ precursors or CD38 inhibitors attenuates age-related placental senescence, rescues intrauterine growth restriction”
Animals
Macrophage CD38 drives age-related placental senescence by depleting NAD+
Nature communications27 Aug 2026
Centre Hospitalier Intercommunal Creteil
1 trialPhase 3500 people
1 trialPhase 3476 people
1 trialPhase 348 people
2 trialsPhase 2168 people
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
1 trialPhase 2154 people
Targeting CD38 or supplementing NAD+ precursors reduces placental aging and improves offspring metabolic health in models of delayed maternal age.Targeting CD38 or supplementing NAD+ precursors reduces placental aging and improves offspring metabolic health in models of delayed maternal age.