Incident symptomatic knee osteoarthritis

1. Sarcopenic obesity is associated with incident symptomatic knee osteoarthritis in humans (Compared to obesity alone) (aOR 2.54, 95% CI 1.20–5.39).

   “Compared to obesity alone, sarcopenic obesity was associated with higher odds of incident sxKOA (adjusted odds ratio [aOR] 2.54, 95% confidence interval [CI] 1.20,5.39)”

   HumansCompared to obesity alonekneesix-year follow-up1/3 malesn = 1,108

   Obesity with poor muscle health linked to worse knee arthritis

   Osteoarthritis and cartilage open·Nov 1, 2026

More on Sarcopenic obesity

1. Dynapenic abdominal obesity is associated with incident symptomatic knee osteoarthritis in humans (Dynapenic abdominal obesity versus neither condition; no knee osteoarthritis at baseline) (HR 1.369, 95% CI 1.050–1.785).

   “D/AO (HR = 1.369, 95% CI: 1.050-1.785)”

   HumansDynapenic abdominal obesity versus neither condition; no knee osteoarthritis at baseline2011–2018n = 11,098

   Association of dynapenic abdominal obesity with prevalence and incidence of symptomatic knee osteoarthritis among the middle-aged and older Chinese

   Aging clinical and experimental research·Apr 19, 2026

More on Dynapenic abdominal obesity

1. Dynapenia is associated with incident symptomatic knee osteoarthritis in humans (HR 1.434, 95% CI 1.167–1.761).

   “D/NAO (HR = 1.434, 95% CI: 1.167-1.761)”

   HumansDynapenia without abdominal obesity versus neither condition; no knee osteoarthritis at baseline2011–2018n = 11,098

   Association of dynapenic abdominal obesity with prevalence and incidence of symptomatic knee osteoarthritis among the middle-aged and older Chinese

   Aging clinical and experimental research·Apr 19, 2026

More on Dynapenia

1. Abdominal obesity is associated with incident symptomatic knee osteoarthritis in humans (HR 1.155, 95% CI 1.059–1.260).

   “ND/AO (HR = 1.155, 95% CI: 1.059-1.260)”

   HumansAbdominal obesity without dynapenia versus neither condition; no knee osteoarthritis at baseline2011–2018n = 11,098

   Association of dynapenic abdominal obesity with prevalence and incidence of symptomatic knee osteoarthritis among the middle-aged and older Chinese

   Aging clinical and experimental research·Apr 19, 2026

More on Abdominal obesity

1. prediction model predicts incident symptomatic knee osteoarthritis in humans (internally validated by bootstrapping) (AUC 0.719 (95% CI 0.700–0.737); optimism-corrected AUC 0.712).

   “The risk model showed good discrimination with AUC = 0.719 (95% confidence interval [CI] 0.700-0.737)”

   Humansinternally validated by bootstrapping4 yearsn = 8,193

   Development of a model for predicting the 4-year risk of symptomatic knee osteoarthritis in China: a longitudinal cohort study

   Arthritis research & therapy·Feb 25, 2021