Incident dermatitis and eczema

1. Circulating metabolites mediate incident dermatitis and eczema in humans (98 significantly mediating metabolites).

   “In metabolomic analyses, 98 circulating metabolites significantly mediated the mLOY-DE association, predominantly lipoprotein-related traits.”

   HumansStatistical mediation of the association between hematopoietic mLOY and dermatitis and eczemamales

   Association of hematopoietic mosaic loss of chromosome Y with dermatitis and eczema risk: an analysis in a large-scale prospective cohort study

   The British journal of dermatology·28 May 2026

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1. Hematopoietic mosaic loss of chromosome Y is associated with incident dermatitis and eczema in humans (aHR 1.44, 95% CI 1.26–1.66).

   “with the strongest association observed for high mLOY [adjusted hazard ratio (aHR) 1.44, 95% CI 1.26-1.66; P <0.001].”

   HumansHigh mLOY (>20%); free of dermatitis and eczema at baseline; fully adjusted modelmalesn = 189,572

   Association of hematopoietic mosaic loss of chromosome Y with dermatitis and eczema risk: an analysis in a large-scale prospective cohort study

   The British journal of dermatology·28 May 2026

More on Hematopoietic mosaic loss of chromosome Y