Hematopoietic mosaic loss of chromosome Y

1. Hematopoietic mosaic loss of chromosome Y is associated with incident dermatitis and eczema in humans (aHR 1.44, 95% CI 1.26–1.66).

   “with the strongest association observed for high mLOY [adjusted hazard ratio (aHR) 1.44, 95% CI 1.26-1.66; P <0.001].”

   HumansHigh mLOY (>20%); free of dermatitis and eczema at baseline; fully adjusted modelmalesn = 189,572

   Association of hematopoietic mosaic loss of chromosome Y with dermatitis and eczema risk: an analysis in a large-scale prospective cohort study

   The British journal of dermatology·28 May 2026

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