2 papers4 findings
Proteomic age acceleration
upin humans1
Impaired kidney function is associated with proteomic age acceleration in humans.
“Within individuals, dyslipidemia and impaired kidney function track transitions to increases in age acceleration”
Humansplasman = 4,100
Blood protein clock tracks shifts in health risks over time
bioRxiv6 Oct 2026Preprint
Deep neural network model
mixedin humans1
deep neural network model predicts impaired kidney function in humans (Accuracy 0.78; recall 0.69; recall 0.78 at threshold 0.4).
“The DNN model showed good predictive performance (accuracy 0.78; recall 0.69), with improved recall (0.78) at a threshold of 0.4.”
HumansIndigenous communities in Odisha, India
The Indian journal of medical research1 Aug 2026
Indigenous adults
mixedin humans1
Indigenous adults are associated with impaired kidney function in humans (Prevalence 24.8% (95% CI 23.8–25.9)).
“Overall, 24.8% [95% confidence interval (CI): 23.8-25.9] of participants had IKF”
HumansIndigenous communities in Odisha, India; eGFR <90 mL/min/1.73m2n = 19,703
The Indian journal of medical research1 Aug 2026
Cardiovascular mortality
upin humans1
Impaired kidney function raises the risk of cardiovascular mortality in humans (HR (95% CI): 1.56 (1.24-1.99)).
“eGFR <45 (compared to ≥45) mL/min/1.73 m 2 were associated with an increased risk of CV mortality ((HR [95% CI]: 1.36 (1.16-1.60) and 1.56(1.24-1.99)), respectively.”
HumanseGFR <45 vs ≥45 mL/min/1.73 m2median follow-up of 18.4 yearsn = 6,057
AHA Scientific Sessions 2025 abstract3 Nov 2025
In an observational study of 4,100 people, accelerated blood protein aging tracked worsening kidney function, blood lipid imbalances, and a higher risk of death.In an observational study of 4,100 people, accelerated blood protein aging tracked worsening kidney function, blood lipid imbalances, and a higher risk of death.
Underweight carried an odds ratio of 1.41 for incident chronic kidney disease compared with no obesity, whereas excess adiposity showed an odds ratio of 1.03.Underweight carried an odds ratio of 1.41 for incident chronic kidney disease compared with no obesity, whereas excess adiposity showed an odds ratio of 1.03.
In 1,195 older adults followed for three years, impaired kidney function raised incident cognitive impairment odds (OR = 1.744) compared to normal function.In 1,195 older adults followed for three years, impaired kidney function raised incident cognitive impairment odds (OR = 1.744) compared to normal function.