There are 5 papers on hip/knee osteoarthritis in aging research: 5 observational studies in people. The newest story, Oct 7, 2026: “Activity’s link to knee and hip arthritis varied with weight”.
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See all 10 papers on hip/knee osteoarthritis
“Among overweight and obese participants, MVPA showed a U-shaped association with knee/hip OA; among normal-weight and underweight participants, a J-shaped association was observed.”
Moderate-to-vigorous physical activity + light physical activity
downin humans1
Moderate-to-vigorous physical activity + light physical activity is associated with hip/knee osteoarthritis in humans (Overweight and obese participants; joint association analysis).
“the combination of moderate MVPA and moderate LPA conferred the lowest OA risk in overweight and obese participants”
HumansOverweight and obese participants; joint association analysisModerate MVPA and moderate LPAMedian follow-up of 10.11 years
Activity’s link to knee and hip arthritis varied with weight
Research SquarePreprint
More on Moderate-to-vigorous physical activity + light physical activity
Moderate-to-vigorous physical activity
mixedin humans1
Moderate-to-vigorous physical activity is associated with hip/knee osteoarthritis in humans.
“Among overweight and obese participants, MVPA showed a U-shaped association with knee/hip OA; among normal-weight and underweight participants, a J-shaped association was observed.”
HumansU-shaped association in overweight and obese participants; J-shaped association in normal-weight and underweight participantsMedian follow-up of 10.11 yearsn = 85,196
Activity’s link to knee and hip arthritis varied with weight
Research SquarePreprint
Parkinson's disease
upin humans1OR 1.23
Hip/knee osteoarthritis is linked with a higher risk of Parkinson's disease in humans (Mendelian randomization using genetic variants as instrumental variables) (OR=1.23, 95% CI 1.03-1.47).
“with a similar effect for combined hip/knee OA (OR=1.23, 95% CI: 1.03-1.47)”
HumansMendelian randomization using genetic variants as instrumental variables
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Vascular dementia
downin humans1
Hip/knee osteoarthritis is linked with a lower risk of vascular dementia in humans (two-sample Mendelian randomization, inverse-variance weighted method).
“Kneehip OA was inversely associated with unspecified dementia and vascular dementia”
Humanstwo-sample Mendelian randomization, inverse-variance weighted method
Frontiers in aging neuroscience
Self-care limitations
upin humans1RR 3.09
Hip/knee osteoarthritis is linked with a higher risk of self-care limitations in combination with anxiety (synergism) (RR 3.09 (95% CI 2.00 to 4.78); RERI 0.93 (95% CI 0.01 to 1.90)).
“Synergistic effects impacting self-care limitations were observed between hip/knee OA and anxiety (RR: 3.09, 95% Confidence Interval (CI): 2.00 to 4.78; RERI: 0.93, 95% CI: 0.01 to 1.90)”
Humansin combination with anxiety (synergism)
Journal of comorbidity
Fractures
upin humans1OR 1.81
Hip/knee osteoarthritis is linked with a higher risk of fractures in humans (first 12 months after diagnosis, compared with people without osteoarthritis) (over 80% greater chance; OR 1.81 (total knee arthroplasty) and 1.84 (total hip arthroplasty)).
“People with knee and hip osteoarthritis demonstrated over an 80% greater chance of experiencing a fracture in the first 12 months of their diagnosis”
Humansfirst 12 months after diagnosis, compared with people without osteoarthritis12 months
International journal of rheumatic diseases
A cohort study following 85,196 people for a median 10.11 years linked moderate activity to the lowest arthritis risk among overweight and obese participants.A cohort study following 85,196 people for a median 10.11 years linked moderate activity to the lowest arthritis risk among overweight and obese participants.