High-impact musculoskeletal pain

1. High-impact musculoskeletal pain is associated with immune and inflammatory transcriptional processes in humans.

   “In women, high-impact pain was associated with broader transcriptional alterations involving immune, inflammatory, metabolic, and cytoskeletal processes.”

   Humansvastus lateralis musclefemales

   Activity-limiting pain linked to muscle gene activity in older adults

   Molecular pain·Oct 18, 2026

1. High-impact musculoskeletal pain is associated with musculoskeletal structural and extracellular matrix pathways in humans.

   “In men, high-impact pain was characterized by enrichment of musculoskeletal structural and extracellular matrix pathways.”

   Humansvastus lateralis musclemales

   Activity-limiting pain linked to muscle gene activity in older adults

   Molecular pain·Oct 18, 2026

1. High-impact musculoskeletal pain is associated with skeletal muscle transcriptomic profile in humans.

   “High-impact musculoskeletal pain was associated with a distinct skeletal muscle transcriptomic profile, whereas minimal differences were observed between low-impact pain and no pain.”

   Humansvastus lateralis musclen = 742

   Activity-limiting pain linked to muscle gene activity in older adults

   Molecular pain·Oct 18, 2026

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