What does the research say about heart failure events?

Heart failure events

There are 5 papers on heart failure events in aging research: 1 trial and 2 observational studies in people, 2 reviews. The newest story, Nov 5, 2026: “Lower blood chloride linked to worse heart failure outcomes”.

Disease

5 papers study it76 more mention it5 findings

13 new papers in 30 daysSee all 81 papers on heart failure events

“experienced 1.3 to 1.7-fold higher rates of HF events and mortality compared to patients with ≥ Q2Na+/ ≥ Q2Cl−.”

Serum sodium and chloride interplay and the effect of empagliflozin in heart failure: an EMPEROR-Pooled analysisClinical research in cardiology : official journal of the German Cardiac Society2026doi:10.1007/s00392-026-03047-6

Human trial1
Humans2

Interventions

Renin-angiotensin system inhibitors, sodium-glucose cotransporter 2 inhibitors, non-steroidal mineralocorticoid receptor antagonists, incretin-based agents

downin reviews1

1 study

Renin-angiotensin system inhibitors, sodium-glucose cotransporter 2 inhibitors, non-steroidal mineralocorticoid receptor antagonists, incretin-based agents decrease heart failure events in high-risk populations.
“demonstrate complementary benefits in reducing HF events, cardiovascular death, and chronic kidney disease (CKD) progression in high-risk populations”
Reviewin high-risk populations
Pharmacological treatment strategies to prevent heart failure across the cardiovascular-kidney-metabolic spectrum: an EJHF Expert Consensus Statement
European journal of heart failureOct 1, 2026

More on Renin-angiotensin system inhibitors, sodium-glucose cotransporter 2 inhibitors, non-steroidal mineralocorticoid receptor antagonists, incretin-based agents

Associations

Low serum sodium and chloride

upin humans1

1 study

Low serum sodium and chloride is associated with heart failure events in humans (1.3 to 1.7-fold higher rates of HF events and mortality).
“experienced 1.3 to 1.7-fold higher rates of HF events and mortality compared to patients with ≥ Q2Na+/ ≥ Q2Cl−.”
HumansAmbulatory heart failure; sodium <140 mmol/L and chloride <99 mmol/L versus both in quintiles 2–5
Lower blood chloride linked to worse heart failure outcomes
Clinical research in cardiology : official journal of the German Cardiac SocietyNov 5, 2026

Latest

43 papers in 12 months

Clinical Research in CardiologyNov 5

Lower blood chloride linked to worse heart failure outcomes

Patients in the lowest fifth for both sodium and chloride had 1.3- to 1.7-fold higher heart failure event and death rates than those with higher levels of both.Patients in the lowest fifth for both sodium and chloride had 1.3- to 1.7-fold higher heart failure event and death rates than those with higher levels of both.

Cohort · 9,718 peopleHeart failure

Paper

ESC Congress 2026 AbstractOct 26

Comparative cardiovascular outcomes of semaglutide versus tirzepatide in patients with atrial fibrillation undergoing catheter ablation: a retrospective cohort study

Cohort study of 1,861 peopleSemaglutide

Paper

European Journal of Heart FailureOct 1

Pharmacological treatment strategies to prevent heart failure across the cardiovascular-kidney-metabolic spectrum: an EJHF Expert Consensus Statement

ReviewCardiovascular-kidney-metabolic syndrome

Paper

Current Problems in CardiologyMar 27

Comparative effectiveness of mineralocorticoid receptor antagonists in cardiovascular, renal and metabolic disease

Cohort study in peopleCardiovascular disease

Paper

JAMA Network OpenNov 5

Indoor radon linked to heart failure in postmenopausal women

Women in counties above 4 picocuries per liter had a heart failure hazard ratio of 1.19 versus those below 2 picocuries per liter.Women in counties above 4 picocuries per liter had a heart failure hazard ratio of 1.19 versus those below 2 picocuries per liter.

Cohort · 43,188 peopleHeart failure