Among older adults with narrowed brain arteries, impaired versus preserved fluid clearance was linked to cognitive worsening, with hazard ratios of 1.35 to 2.96.Among older adults with narrowed brain arteries, impaired versus preserved fluid clearance was linked to cognitive worsening, with hazard ratios of 1.35 to 2.96.
Who was studied291 older adults, median 5.7 years, against adults with stenosis and high DTI-ALPS
What changedCognitive worsening was more likely with impaired versus preserved estimated fluid clearance in adults with narrowed brain arteries (hazard ratio 2.96)
The catchBrain atrophy can confound DTI-ALPS, the marker used to infer fluid clearance
In a 429-person sleep intervention study, proposed brain-scan measures of waste clearance responded differently to restricted sleep and prolonged wakefulness.In a 429-person sleep intervention study, proposed brain-scan measures of waste clearance responded differently to restricted sleep and prolonged wakefulness.
In human imaging and post-mortem brain data, glymphatic impairment occurred in an inflammatory subgroup and tracked with accelerated brain and epigenetic aging.In human imaging and post-mortem brain data, glymphatic impairment occurred in an inflammatory subgroup and tracked with accelerated brain and epigenetic aging.