CNS Neuroscience & Therapeutics
Impaired brain fluid clearance linked to cognitive decline
Among older adults with narrowed brain arteries, impaired versus preserved fluid clearance was linked to cognitive worsening, with hazard ratios of 1.35 to 2.96.Among older adults with narrowed brain arteries, impaired versus preserved fluid clearance was linked to cognitive worsening, with hazard ratios of 1.35 to 2.96.
Cohort · 291 peopleMechanisms
Who was studied291 older adults, median 5.7 years, against adults with stenosis and high DTI-ALPS
What changedCognitive worsening was more likely with impaired versus preserved estimated fluid clearance in adults with narrowed brain arteries (hazard ratio 2.96)
The catchBrain atrophy can confound DTI-ALPS, the marker used to infer fluid clearance