Genital mycotic infections

1. SGLT2 inhibitors raise the risk of genital mycotic infections in humans.

   “flozins are associated with risks including genital mycotic infections, euglycemic ketoacidosis”

   Review

   From molecules to the clinic-pathophysiology of sodium-glucose cotransporter 2 inhibitors and their emerging role in urology: A comprehensive review from the European Association of Urology Section of Endourology

   Asian journal of urology·24 Apr 2026

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1. Canagliflozin raises the risk of genital mycotic infections in humans (women: 11% and 14% vs 2%; men: 7% and 8% vs 1%).

   “In the canagliflozin 100 mg and 300 mg groups versus the glimepiride group, we recorded a greater number of genital mycotic infections”

   Human trialtype 2 diabetes inadequately controlled with metformin52 weeks

   Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial

   Lancet (London, England)·12 Jul 2013

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