Functional hypothalamic amenorrhea

Disease1 paper3 findings

  • Humans1

Associations

3

Type 2 diabetes

upin humans1HR 1.86

1 study
  1. Functional hypothalamic amenorrhea raises the risk of type 2 diabetes in humans (HR = 1.86; 95% CI: 1.41-2.47).

    Humansin mid-adulthoodup to 26 yearsfemalesn = 52,655

    Hypothalamic amenorrhea in mid-adulthood linked to heart disease · The Journal of clinical endocrinology and metabolism · 5 Oct 2026

Type 2 diabetes →

Coronary heart disease

upin humans1HR 1.91

1 study
  1. Functional hypothalamic amenorrhea raises the risk of coronary heart disease in humans (HR = 1.91; 95% CI: 1.11-3.27).

    Humansin mid-adulthoodup to 26 yearsfemalesn = 52,655

    Hypothalamic amenorrhea in mid-adulthood linked to heart disease · The Journal of clinical endocrinology and metabolism · 5 Oct 2026

Coronary heart disease →

Cardiovascular disease

upin humans1

1 study
  1. Functional hypothalamic amenorrhea raises the risk of cardiovascular disease in humans (62% higher risk (95% CI: 1.01-2.59)).

    Humansin mid-adulthoodup to 26 yearsfemalesn = 52,655

    Hypothalamic amenorrhea in mid-adulthood linked to heart disease · The Journal of clinical endocrinology and metabolism · 5 Oct 2026

Cardiovascular disease →

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The Journal of Clinical Endocrinology and MetabolismHumans

Hypothalamic amenorrhea in mid-adulthood linked to heart disease

Mid-adulthood functional hypothalamic amenorrhea was linked to a 62% higher cardiovascular disease risk and an HR of 1.91 for coronary heart disease…Mid-adulthood functional hypothalamic amenorrhea was linked to a 62% higher cardiovascular disease risk and an HR of 1.91 for coronary heart disease compared to regular cycles.