Critical limb ischemia
Disease1 paper2 findings
- Humans1
Associations
2Homocitrulline
upin humans1
1 study
Homocitrulline
upin humans1
Homocitrulline is associated with critical limb ischemia in humans.
Humansafter adjustment for traditional risk factors27 yearsn = 3,759
Metabolites Associated With Long-Term Risk of Peripheral Artery Disease: The ARIC Study · Arteriosclerosis, thrombosis, and vascular biology · 27 Aug 2026
Circulating metabolites
upin humans1
1 study
Circulating metabolites
upin humans1
Circulating metabolites predict critical limb ischemia in humans (∆C statistic, 0.041 [95% CI, 0.018-0.064]).
Humansprospective cohort with median follow-up of 27 years27 yearsn = 3,759
Metabolites Associated With Long-Term Risk of Peripheral Artery Disease: The ARIC Study · Arteriosclerosis, thrombosis, and vascular biology · 27 Aug 2026
Trial sponsors
Company1 trialPhase 1/220 people
University of California, San Francisco
1 trialPhase 433 people
1 trialPhase 432 people
1 trialPhase 2/330 people
Ottawa Hospital Research Institute
1 trialPhase 220 people
1 trialPhase 1/250 people
Federal Research Clinical Center of Federal Medical & Biological Agency, Russia
1 trialPhase 1/240 people
Washington University School of Medicine
1 trialEarly phase 133 people