Clinical anxiety

1. Physical activity raises the risk of clinical anxiety in humans (HR 1.16, 95% CI 1.05-1.28).

   “Higher midlife overall physical activity (HR=1.16, 95% CI=1.05-1.28, p=0.003) and MVPA (HR=1.12, 95% CI=1.02-1.23, p=0.019) were associated with an increased risk for new-onset clinical anxiety”

   Humansmidlifemedian 5.6 yearsn = 2,444

   Associations of Mid- and Late-Life Physical Activities With New-Onset Depression and Anxiety Among Older Adults

   The Journal of neuropsychiatry and clinical neurosciences·Apr 28, 2025

2. Physical activity lowers the risk of clinical anxiety in humans (HR 0.79, 95% CI 0.71-0.89).

   “Higher late-life overall physical activity (HR=0.79, 95% CI=0.71-0.89, p<0.001) and moderate-to-vigorous physical activity (MVPA; HR=0.86, 95% CI=0.77-0.95, p=0.003) were associated with a decreased risk for incident clinical anxiety.”

   Humanslate lifemedian 5.6 yearsn = 2,444

   Associations of Mid- and Late-Life Physical Activities With New-Onset Depression and Anxiety Among Older Adults

   The Journal of neuropsychiatry and clinical neurosciences·Apr 28, 2025

3. Physical activity lowers the risk of clinical anxiety in humans (OR=0.90, 95% CI=0.86-0.94).

   “clinical anxiety (OR=0.90, 95% CI=0.86-0.94), as well as lower BDI-II (β estimate=-0.042, 95% CI=-0.051 to -0.033) and BAI (β estimate=-0.030, 95% CI=-0.040 to -0.021) scores.”

   Humansadjusted for age, sex, education, APOE ɛ4, medical comorbidityn = 3,222

   Mid- and Late-Life Physical Activity and Neuropsychiatric Symptoms in Dementia-Free Older Adults: Mayo Clinic Study of Aging

   The Journal of neuropsychiatry and clinical neurosciences·Dec 5, 2022

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