Chronic intestinal failure

1. Chronic intestinal failure impairs cognitive function in humans (92.9% abnormal).

   “92.9 % showed abnormal cognitive performance on the Montreal Cognitive Assessment, with scores considered low for their age and educational level”

   Humanschronic intestinal failure on home parenteral nutritionn = 14

   Geriatric syndromes in intestinal failure: An accelerated aging phenomenon in middle adulthood patients?

   Clinical nutrition ESPEN·28 Oct 2025

1. Chronic intestinal failure increases PhenoAge in humans (median 67.5 vs mean 58.3 years).

   “mean chronological age was 58.3 ± 13 years, while the median phenotypic age, according to PhenoAge, was 67.5 (60.5-82.5) years-indicating premature metabolic aging in this population”

   Humanschronic intestinal failure on home parenteral nutritionn = 14

   Geriatric syndromes in intestinal failure: An accelerated aging phenomenon in middle adulthood patients?

   Clinical nutrition ESPEN·28 Oct 2025

More on PhenoAge

1. Chronic intestinal failure raises the risk of frailty in humans (92.9%).

   “92.9 % were classified as frail based on deficit accumulation using the Clinical Frailty Scale”

   Humanschronic intestinal failure on home parenteral nutritionn = 14

   Geriatric syndromes in intestinal failure: An accelerated aging phenomenon in middle adulthood patients?

   Clinical nutrition ESPEN·28 Oct 2025