Brain health events

1. Epigenetic age predicts brain health events in humans (OR = 1.70, 95% CI = 1.16-2.50).

   “a one standard deviation increase in epigenetic age is associated with 70% higher odds of experiencing a brain health event in the next four years (OR = 1.70, 95% CI = 1.16-2.50)”

   Humansfour years

   Bidirectional relationship between epigenetic age and stroke, dementia, and late-life depression

   Nature communications·1 Feb 2025

2. Brain health events are associated with epigenetic age in humans (4% epigenetically older (β = 0.04, SE = 0.01)).

   “Participants with a prior brain health event are 4% epigenetically older (β = 0.04, SE = 0.01)”

   Humans

   Bidirectional relationship between epigenetic age and stroke, dementia, and late-life depression

   Nature communications·1 Feb 2025

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