Bicuspid aortic valve aortopathy

Bicuspid aortic valve aortopathy is associated with aberrant vascular maturation in humans.

“Lifespan analyses indicate that TAV follows a maturation-stabilisation-degeneration trajectory, whereas BAV exhibits aberrant vascular maturation without a true stabilisation phase.”

Reviewascending aorta

From maturation to degeneration: Distinct biological trajectories in bicuspid and tricuspid aortopathy

Experimental physiology·13 Oct 2026