Alzheimer's disease neuropathologic change

1. Alzheimer's disease neuropathologic change increases integrated stress response in human cells.

   “with a pronounced expansion of the Stress/ISR-reactive compartment and altered transition-associated pathway enrichment in high ADNC WM.”

   Cellsin white matter oligodendrocyteswhite mattern = 48

   Single nucleus RNA sequencing and spatial transcriptomics reveal unique functionalities of gray matter versus white matter oligodendrocytes in aging and Alzheimer's Disease · bioRxiv · 3 Sep 2026 · Preprint

Integrated stress response →

1. Alzheimer's disease neuropathologic change increases proteostasis in human cells.

   “High ADNC WM OLs also displayed amplified proteostasis and stress-adaptation signatures, including selective upregulation of chaperone/heat shock genes and ferritin subunits”

   Cellsin high ADNC WM oligodendrocyteswhite mattern = 48

   Single nucleus RNA sequencing and spatial transcriptomics reveal unique functionalities of gray matter versus white matter oligodendrocytes in aging and Alzheimer's Disease · bioRxiv · 3 Sep 2026 · Preprint

Proteostasis →