Single nucleus RNA sequencing and spatial transcriptomics reveal unique functionalities of gray matter versus white matter oligodendrocytes in aging and Alzheimer's Disease
bioRxiv
Abstract
Oligodendrocyte (OL) dysfunction and white-matter (WM) vulnerability are increasingly recognized as important aspects of aging and Alzheimer's Disease (AD), yet human WM-focused, cellular-resolution transcriptomic data remain limited.
- Immune response
- Inflammation
- Integrated stress response
- Alzheimer's disease
- Alzheimer's disease neuropathologic change
- Humans
The paper
Voth JP, Ramos Benitez JA, Wilson AM et al.
bioRxiv · 3 Sep 2026 · CC BY · Preprint, not peer-reviewed
