Alcohol-associated hepatitis

3 papers1 finding

Humans2
Animals1

Associations

1

Senescence-associated secretory phenotype (SASP)

upin humans1

1 study

Alcohol-associated hepatitis is associated with senescence-associated secretory phenotype (SASP) in humans.
“Transcriptomic analysis revealed an increased expression of senescence-associated genes and an enrichment of SASP gene signatures in patients with cirrhosis and particularly with AH.”
Humanscirrhosis and alcohol-associated hepatitisliver
GDF15 is associated with hepatocellular senescence and correlates with mortality in patients with alcohol-associated hepatitis
JHEP reports : innovation in hepatologyJun 10, 2025

More on Senescence-associated secretory phenotype (SASP)

Trial sponsors

Samer Gawrieh
1 trialPhase 2216 people

Latest

JHEP ReportsAug 14

GDF15 is associated with hepatocellular senescence and correlates with mortality in patients with alcohol-associated hepatitis

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Science AdvancesJun 27

Hepatic NMNAT1 is required to defend against alcohol-associated fatty liver disease

Experiments in miceInterventions

GutMar 24

Longitudinal paired liver biopsies and transcriptome profiling in alcohol-associated hepatitis reveal dynamic changes in cellular senescence

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