WMH global-PRS

1. WMH global-PRS raises the risk of dementia in humans (HR 1.051 [1.030, 1.080]).

   Humansn = 355,180

   Pathway-specific polygenic risk scores reveal underlying mechanisms of cerebral small vessel disease · medRxiv · 14 Sep 2026 · Preprint

Dementia →

1. WMH global-PRS raises the risk of stroke in humans (HR 1.06 [1.038, 1.082]).

   Humansn = 355,180

   Pathway-specific polygenic risk scores reveal underlying mechanisms of cerebral small vessel disease · medRxiv · 14 Sep 2026 · Preprint

Stroke →

1. WMH global-PRS predicts white matter hyperintensities in humans (Delta R2=+4.1%, P=1.78x10-193).

   Humans

   Pathway-specific polygenic risk scores reveal underlying mechanisms of cerebral small vessel disease · medRxiv · 14 Sep 2026 · Preprint

White matter hyperintensities →