Vitamin B12
Biomarker2 papers1 finding
- Humans2
Interventions
1Metformin
downin humans1
1 study
Metformin
downin humans1
Metformin decreases vitamin B12 in humans (569.3 vs. 825.3 pg/mL).
Humanstype 2 diabetesn = 587
Metformin Use Is Associated With Better Cognitive Performance in Older Adults With Type 2 Diabetes: Exploratory Analysis of Vitamin B12 and Methylmalonic Acid Pathways in NHANES 2011-2014 · Diabetes, obesity & metabolism · 28 Sep 2026
Latest
5High serum vitamin B12 links to cancer and mortality
Cancer incidence increased with adjusted hazard ratios of 1.05 to 1.08 above the 400–600 pg/mL reference, while mortality showed a J-shaped pattern.Cancer incidence increased with adjusted hazard ratios of 1.05 to 1.08 above the 400–600 pg/mL reference, while mortality showed a J-shaped pattern.
Nutrient deficiencies raise metabolic risk in obesity
In patients with obesity, vitamin D, vitamin B12, and prior underweight showed the greatest metabolic hazards, with median hazard ratios of 3.09…In patients with obesity, vitamin D, vitamin B12, and prior underweight showed the greatest metabolic hazards, with median hazard ratios of 3.09, 2.49, and 2.23.