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Vascular TfR expression

Biomarker

1 paper2 findings

  • Humans1

Upstream

1

Alzheimer's disease

no changein humans1

1 study

  1. Alzheimer's disease has no effect on vascular TfR expression in humans.

    “vascular TfR expression in AD patient brains was similar to age-matched controls”

    HumansAD patients compared with age-matched controlsbrain vasculature

    Transferrin receptor-mediated transport at the blood-brain barrier is elevated during early development but maintained across adult aging

    bioRxiv (Cold Spring Harbor Laboratory)14 Nov 2024Preprint

More on Alzheimer's disease

Associations

1

Early development

upin mice1

1 study

  1. Early development is associated with vascular TfR expression in mice (Highest expression in neonates).

    “Healthy neonates exhibited the highest vascular TfR expression and ATV TfR brain exposure, whereas BBB transport capacity remained stable across adulthood.”

    Animalshealthy micebrain vasculature

    Transferrin receptor-mediated transport at the blood-brain barrier is elevated during early development but maintained across adult aging

    bioRxiv (Cold Spring Harbor Laboratory)14 Nov 2024Preprint

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