Unscheduled DNA synthesis

1. Ultraviolet radiation decreases unscheduled DNA synthesis in mice.

   “in aged mice the UDS level decreased markedly with increase in the dose, whereas in young mice it remained at the same level”

   Animalshigh doses of UV irradiationskin epithelial cells

   In vivo studies on DNA repair and turnover with age

   Basic life sciences·1 Jan 1985

More on Ultraviolet radiation

1. Unscheduled DNA synthesis is associated with lifespan in mouse cells.

   “The capacity for induction of unscheduled DNA synthesis was different in the cells of each strain and correlated to the natural life span of the animal.”

   CellsComparison of three inbred mouse strainsembryonic fibroblast

   Correlation between DNA repair of embryonic fibroblasts and different life span of 3 inbred mouse strains

   Mechanisms of ageing and development·1 Feb 1978

2. Lifespan is associated with unscheduled DNA synthesis in Mammalia cells.

   “Unscheduled DNA synthesis was approximately proportional to the logarithm of life-span.”

   Cellsafter UV irradiation

   Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species

   Proceedings of the National Academy of Sciences of the United States of America·1 Jun 1974