1 paper3 findings
Clinical Dementia Rating Sum of Boxes score
upin humans1
Ten-year ASCVD risk is associated with clinical Dementia Rating Sum of Boxes score in humans (β range 0.28 (95% CI 0.09–0.46) to 0.39 (95% CI 0.20–0.58)).
“increased CDR Sum of Boxes scores, ranging from β = 0.28 (95% CI: 0.09-0.46) to β = 0.39 (95% CI: 0.20-0.58).”
HumansAcross multivariable models; association magnitude varied across racial and ethnic groups
Cardiovascular risk linked to mild cognitive impairment
Frontiers in aging neuroscience28 Sep 2026
Mini-Mental State Examination score
downin humans1
Ten-year ASCVD risk is associated with mini-Mental State Examination score in humans (β range −1.90 (95% CI −2.62 to −1.18) to −2.56 (95% CI −3.30 to −1.82)).
“lower MMSE scores, ranging from β = -1.90 (95% CI: -2.62 to -1.18) to β = -2.56 (95% CI: -3.30 to -1.82)”
HumansAcross multivariable models
Cardiovascular risk linked to mild cognitive impairment
Frontiers in aging neuroscience28 Sep 2026
Mild cognitive impairment
upin humans1OR 2.62
Ten-year ASCVD risk is associated with mild cognitive impairment in humans (OR range 2.62 (95% CI 1.31–5.17) to 4.22 (95% CI 2.04–8.64)).
“Increased ten-year ASCVD risk was consistently associated with increased odds of MCI”
HumansAcross models including plasma biomarkers or APOE ε4 carrier status
Cardiovascular risk linked to mild cognitive impairment
Frontiers in aging neuroscience28 Sep 2026
Greater estimated cardiovascular risk was linked to higher odds of mild cognitive impairment; reported odds ratios ranged from 2.62 to 4.22 across models.Greater estimated cardiovascular risk was linked to higher odds of mild cognitive impairment; reported odds ratios ranged from 2.62 to 4.22 across models.