What does the research say about stress and inflammatory proteins in brain extracellular space?

Stress and inflammatory proteins in brain extracellular space

There are 2 papers on stress and inflammatory proteins in brain extracellular space in aging research: none in people yet, 2 in animals. The newest story, Oct 30, 2026: “Protein reduces brain immune cell activation in aged mice”.

Biomarker

2 papers study it2 findings

See all 2 papers on stress and inflammatory proteins in brain extracellular space

Animals2

Upstream

TIMP2

downin mice2

2 studies

TIMP2 decreases stress and inflammatory proteins in brain extracellular space in mice (shown by deletion).
“elevated levels of stress and inflammatory proteins in the brain extracellular space measured by in vivo microdialysis”
Animalsshown by deletionbrain
Protein reduces brain immune cell activation in aged mice
Nature communicationsAug 12, 2026
TIMP2 decreases stress and inflammatory proteins in brain extracellular space in mice (shown by knockout).
“increased levels of stress and inflammatory proteins measured in the brain extracellular space by in vivo microdialysis”
Animalsshown by knockoutbrain
Youth-associated protein TIMP2 alters microglial state and function in the context of aging
bioRxiv : the preprint server for biologyJun 6, 2025Preprint

Latest

1 paper in 12 months

Nature CommunicationsAug 13

Protein reduces brain immune cell activation in aged mice

Aged mice given eight injections of a youth-associated protein had a smaller share of inflammation-promoting brain immune cells than controls.Aged mice given eight injections of a youth-associated protein had a smaller share of inflammation-promoting brain immune cells than controls.

Mouse studyMechanisms

Paper

bioRxivJun 6

Youth-associated protein TIMP2 alters microglial state and function in the context of aging

Preprint: experiments in miceInterventions