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TIMP2

Intervention

1 paper studies it3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • 3 of 3 findings with company ties
  • Animals1

Outcomes

3

FOS

upin mice1

1 study

  1. TIMP2 increases FOS in mice.

    “increased hippocampal cfos gene expression”

    Animalsrecombinant protein or IgG4Fc fusionhippocampusone monthmales

    Noncanonical Activity of Tissue Inhibitor of Metalloproteinases 2 (TIMP2) Improves Cognition and Synapse Density in Aging

    eNeuroJun 15, 2023

More on FOS

Synapse density

upin mice1

1 study

  1. TIMP2 increases synapse density in mice.

    “increased excitatory synapse density in the CA1 and dentate gyrus (DG) of the hippocampus”

    Animalsrecombinant protein or IgG4Fc fusionhippocampusone monthmales

    Noncanonical Activity of Tissue Inhibitor of Metalloproteinases 2 (TIMP2) Improves Cognition and Synapse Density in Aging

    eNeuroJun 15, 2023

Hippocampal-dependent memory

upin mice1

1 study

  1. TIMP2 improves hippocampal-dependent memory in mice.

    “23-month-old male C57BL/6J mice showed improved hippocampal-dependent memory in a Y-maze”

    Animalsrecombinant protein or IgG4Fc fusionhippocampusone monthmales

    Noncanonical Activity of Tissue Inhibitor of Metalloproteinases 2 (TIMP2) Improves Cognition and Synapse Density in Aging

    eNeuroJun 15, 2023

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