STAT6 phosphorylation at Ser817

1. Chronic obstructive pulmonary disease is associated with STAT6 phosphorylation at Ser817 in humans.

   “phosphorylation of human STAT6 at the homologous residue (Ser817) is significantly reduced in the lungs of patients with chronic obstructive pulmonary disease (COPD)”

   Humansin COPD lungslung

   DNA-PK-mediated phosphorylation of STAT6 establishes a non-canonical type 2 immunity axis to prevent macrophage senescence

   Nature communications·24 Feb 2026

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