Nature Communications
TET2 loss alters DNA copying during drug treatment in cells
Lab experiments showed that Olaparib treatment lengthened copied DNA tracts, increased DNA breaks and heightened drug sensitivity in cells lacking TET2, but not DNMT3A.Lab experiments showed that Olaparib treatment lengthened copied DNA tracts, increased DNA breaks and heightened drug sensitivity in cells lacking TET2, but not DNMT3A.
Experiments in laboratory-grown cells, against cells lacking DNMT3ATET2
Limit: The proposed sequence from damaged DNA sites to breaks remains a theoretical model