Somatic single nucleotide variants
Biomarker1 paper1 finding
- Humans1
Effects
1Genomic instability
upin human cells1
1 study
Genomic instability
upin human cells1
Somatic single nucleotide variants increase genomic instability in human cells (>12-fold).
Cellsat end of life compared to mouse neuronscerebral cortical neuron
Human neurons accumulate far more mutations over lifespan than shorter-lived mammals · bioRxiv : the preprint server for biology · 24 Sep 2026 · Preprint
Latest
1Human neurons accumulate far more mutations over lifespan than shorter-lived mammals
Cortical neurons gain mutations at similar yearly rates across six species, leaving aged humans with uniquely high mutational burdens and transcriptomic dysregulation.