Soluble Aβ40−42

1. female sex increases soluble Aβ40−42 in mice.

   “females having significantly higher Aβ40−42 at 7-8 months of age”

   Animalstrisomic Ts65Dnbasal forebrainfemales

   Temporal and brain region-specific elevations of soluble Amyloid-β₄₀₋₄₂ in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease

   Aging cell·Mar 15, 2022

1. TS65DNGENOTYPE increases soluble Aβ40−42 in mice.

   “trisomic mice accumulate soluble Aβ40−42 in the basal forebrain, frontal cortex, hippocampus, and cerebellum in an age-specific manner, with elevation in the frontal cortex and hippocampus as early as 4 months of age”

   Animalstrisomybrain

   Temporal and brain region-specific elevations of soluble Amyloid-β₄₀₋₄₂ in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease

   Aging cell·Mar 15, 2022

More on TS65DNGENOTYPE

1. APP is associated with soluble Aβ40−42 in mice.

   “APP expression in the basal forebrain and hippocampus inversely correlates with Aβ40−42 levels”

   Animalstrisomic Ts65Dnbasal forebrain and hippocampus

   Temporal and brain region-specific elevations of soluble Amyloid-β₄₀₋₄₂ in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease

   Aging cell·Mar 15, 2022

More on APP