Serum uric acid variation

1. Serum uric acid variation raises the risk of heart failure in humans (HR 1.31, 95% CI 1.12-1.54).

   “One study also reported an increased risk of heart failure-related outcomes (HR 1.31, 95% CI 1.12-1.54).”

   Humans

   Longitudinal Serum Uric Acid Variation and Risk of Major Adverse Cardiovascular Events and Mortality: A Systematic Review and Meta-Analysis

   Clinical cardiology·1 Sep 2026

More on Heart failure

1. Serum uric acid variation raises the risk of cardiovascular mortality in humans (pooled HR 1.25, 95% CI 1.10-1.42).

   “and cardiovascular mortality (pooled HR 1.25, 95% CI 1.10-1.42; I2 = 48%)”

   Humansn = 160,640

   Longitudinal Serum Uric Acid Variation and Risk of Major Adverse Cardiovascular Events and Mortality: A Systematic Review and Meta-Analysis

   Clinical cardiology·1 Sep 2026

1. Serum uric acid variation raises the risk of cardiovascular disease in humans (pooled HR 1.21, 95% CI 1.11-1.32).

   “incident cardiovascular disease/MACE (pooled HR 1.21, 95% CI 1.11-1.32; I2 = 55%)”

   Humansn = 160,640

   Longitudinal Serum Uric Acid Variation and Risk of Major Adverse Cardiovascular Events and Mortality: A Systematic Review and Meta-Analysis

   Clinical cardiology·1 Sep 2026

More on Cardiovascular disease

1. Serum uric acid variation raises the risk of mortality in humans (pooled HR 1.18, 95% CI 1.10-1.27).

   “Greater longitudinal SUA variation was associated with an increased risk of all-cause mortality (pooled HR 1.18, 95% CI 1.10-1.27; I2 = 62%)”

   Humansn = 160,640

   Longitudinal Serum Uric Acid Variation and Risk of Major Adverse Cardiovascular Events and Mortality: A Systematic Review and Meta-Analysis

   Clinical cardiology·1 Sep 2026