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Senescence and SASP transcriptional signatures

There is 1 paper on senescence and SASP transcriptional signatures in aging research: none in people yet, 1 in animals. The newest story, Nov 5, 2026: “Patient muscles show early signs of cell senescence”.

Biomarker

1 paper studies it1 finding

1 new paper in 30 daysSee all 1 papers on senescence and SASP transcriptional signatures

“strong enrichment of senescence and senescence-associated secretory phenotype (SASP) programs that correlated with DUX4 activity, clinical severity, and histopathological changes.”
Cellular senescence mediates facioscapulohumeral muscular dystrophyThe Journal of clinical investigation2026doi:10.1172/jci207716
  • Animals1

Associations

1

Clinical severity of facioscapulohumeral muscular dystrophy

upin humans1

1 study

  1. Senescence and SASP transcriptional signatures are associated with clinical severity of facioscapulohumeral muscular dystrophy in humans (facioscapulohumeral muscular dystrophy).

    “strong enrichment of senescence and senescence-associated secretory phenotype (SASP) programs that correlated with DUX4 activity, clinical severity, and histopathological changes.”

    Humansfacioscapulohumeral muscular dystrophyskeletal muscle

    Patient muscles show early signs of cell senescence

    The Journal of clinical investigation

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 0Nov 2026: 11 paper in 12 months
The Journal of Clinical Investigation

Patient muscles show early signs of cell senescence

An analysis of patient muscle gene activity found senescence-related patterns linked to disease severity and present even without inflammation visible on scans.An analysis of patient muscle gene activity found senescence-related patterns linked to disease severity and present even without inflammation visible on scans.

Cross-sectional studyCellular senescence
Paper

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