SASP protein score

1. SASP protein score predicts dementia in humans (HRs: midlife 1.20-1.33; late-life 1.39-1.50 (ARIC); midlife 1.28-1.38; late-life 1.40-1.62 (MESA)).

   “Comparable significant associations were observed across scores in ARIC (per 1 SD: HRs: midlife 1.20-1.33; late-life 1.39-1.50) and MESA (midlife: 1.28-1.38; late-life 1.40-1.62)”

   Humansper 1 SD increase

   Senescence protein signatures predict dementia risk with causal implication for TBCA: a two-cohort study

   Research square·26 Mar 2026Preprint

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