Sarcoplasmic reticulum Ca2+ concentration

1. Cellular senescence decreases sarcoplasmic reticulum Ca2+ concentration in human cells (Dox-induced senescent-like iCMs compared with untreated iCMs).

   “Moreover sarcoplasmic reticulum (SR) Ca2+ content was reduced because of downregulated SERCA2 and increased RyR2-mediated Ca2+ leak.”

   CellsDox-induced senescent-like iCMs compared with untreated iCMs0.2 μM doxorubicin3 hours

   Stress-induced premature senescence is associated with a prolonged QT interval and recapitulates features of cardiac aging

   Theranostics·Jul 4, 2022

More on Cellular senescence

1. ryanodinereceptor decreases sarcoplasmic reticulum Ca2+ concentration in aging muscle, via increased leak.

   “these changes are compatible with increased leakiness through the ryanodine receptor as the main determinant of the [Ca2+]SR decline in aging muscle.”

   Model organismsin aging muscle, via increased leakmuscle

   Sarcoplasmic reticulum Ca²⁺ decreases with age and correlates with the decline in muscle function in Drosophila

   Journal of cell science·Jan 31, 2020

More on ryanodinereceptor

1. Sarcoplasmic reticulum Ca2+ concentration is associated with muscle function in flies with age (~600 μM to 50 μM).

   “[Ca2+]SR fell with age from ∼600 μM to 50 μM in close correlation with muscle function”

   Model organismswith agemuscle

   Sarcoplasmic reticulum Ca²⁺ decreases with age and correlates with the decline in muscle function in Drosophila

   Journal of cell science·Jan 31, 2020