Rotterdam Healthy Aging Score

1. Rotterdam Healthy Aging Score has no effect on gut microbiome diversity in humans.

   “Gut microbiome diversity did not differ based on HAS category”

   Humansin older adults with HIVn = 158

   Gut microbiome and healthy aging in HIV: data from the correlates of healthy aging in geriatric HIV (CHANGE HIV) cohort

   AIDS (London, England)·21 Nov 2025

1. D-dimer has no effect on Rotterdam Healthy Aging Score in humans.

   “CRP (median 1.75, IQR 0.711, 4.29) ug/ml and D-Dimer (median 0.362, IQR 0.209–0.846) ug/ml did not show a clear association with HAS.”

   Humansolder adults living with HIVserumpredominantly male (92%)s

   A cohort study of growth differentiating factor - 15 (GDF-15) and Interleukin-6 (IL-6) as biomarkers of healthy aging in older adults living with HIV

   BMC geriatrics·23 Dec 2025

More on D-dimer

1. C-reactive protein has no effect on Rotterdam Healthy Aging Score in humans.

   “CRP (median 1.75, IQR 0.711, 4.29) ug/ml and D-Dimer (median 0.362, IQR 0.209–0.846) ug/ml did not show a clear association with HAS.”

   Humansolder adults living with HIVserumpredominantly male (92%)s

   A cohort study of growth differentiating factor - 15 (GDF-15) and Interleukin-6 (IL-6) as biomarkers of healthy aging in older adults living with HIV

   BMC geriatrics·23 Dec 2025

More on C-reactive protein

1. IL-6 is associated with Rotterdam Healthy Aging Score in humans (R = -0.27, p < 0.001).

   “GDF-15 and IL-6 levels were negatively associated with the HAS (R = -0.35 and − 0.27), p < 0.001 for both comparisons.”

   Humansolder adults living with HIVserumpredominantly male (92%)s

   A cohort study of growth differentiating factor - 15 (GDF-15) and Interleukin-6 (IL-6) as biomarkers of healthy aging in older adults living with HIV

   BMC geriatrics·23 Dec 2025

More on IL-6

1. GDF-15 is associated with Rotterdam Healthy Aging Score in humans (R = -0.35, p < 0.001).

   “GDF-15 and IL-6 levels were negatively associated with the HAS (R = -0.35 and − 0.27), p < 0.001 for both comparisons.”

   Humansolder adults living with HIVserumpredominantly male (92%)s

   A cohort study of growth differentiating factor - 15 (GDF-15) and Interleukin-6 (IL-6) as biomarkers of healthy aging in older adults living with HIV

   BMC geriatrics·23 Dec 2025

More on GDF-15

1. Rotterdam Healthy Aging Score is associated with disease-associated bacteria in humans.

   “some disease-associated bacteria were enriched in participants with lower HAS.”

   Humansin older adults with HIVn = 158

   Gut microbiome and healthy aging in HIV: data from the correlates of healthy aging in geriatric HIV (CHANGE HIV) cohort

   AIDS (London, England)·21 Nov 2025

More on Disease-associated bacteria