Residual variance

1. Caloric restriction decreases residual variance in rats (87% rescue, 95% CI 82-91%).

   “Caloric restriction in rat partially reverses aging-associated pi loss in marrow by reducing residual variance rather than restoring tissue-specific variance (87% rescue; bootstrap 95% CI 82-91%”

   Animalsaging-associated pi loss in marrowbone marrow

   Transcriptomic noise accumulates within tissue identity across human aging: a systemic signature distinct from cell-composition drift

   Zenodo (CERN European Organization for Nuclear Research)·1 May 2026Preprint

More on Caloric restriction