Rate of pi tissue decline

Lifespan is associated with rate of pi tissue decline in silico (alpha = -1.02 +/- 0.24, R-squared = 0.90, Spearman rho = -1.0).

“rate of pi_tissue decline scales inversely with maximum lifespan (alpha = -1.02 +/- 0.24, R-squared = 0.90, Spearman rho = -1.0)”

In silicoaging

Transcriptomic noise accumulates within tissue identity across human aging: a systemic signature distinct from cell-composition drift

Zenodo (CERN European Organization for Nuclear Research)·1 May 2026Preprint