Proteomic brain age gap

1. Proteomic brain age gap is associated with white matter hyperintensities in humans.

   “These findings were corroborated by Magnetic resonance imaging (MRI) assessments showing that a higher brain age gap aligns with cortex atrophy and increased white matter hyperintensity.”

   Humanshigher brain age gapbrain

   PROTEOMIC BRAIN AGE GAP, DEMENTIA RISK, AND BRAIN VOLUME MEASUREMENTS · GSA 2024 abstract · 31 Dec 2024

White matter hyperintensities →

1. Proteomic brain age gap raises the risk of vascular dementia in humans (HR 1.91, 95% CI 1.58-2.31).

   “AD (2.12 [1.88-2.39]), and vascular dementia (1.91 [1.58-2.31]), respectively.”

   Humansper-unit increment in brain age gap z-scoreplasman = 45,113

   PROTEOMIC BRAIN AGE GAP, DEMENTIA RISK, AND BRAIN VOLUME MEASUREMENTS · GSA 2024 abstract · 31 Dec 2024

Vascular dementia →

1. Proteomic brain age gap raises the risk of Alzheimer's disease in humans (HR 2.12, 95% CI 1.88-2.39).

   “Per-unit increment in the brain age gap z-score was associated with significantly elevated risks of all-cause dementia (hazard ratio [95% confidence interval], 1.82 [1.69-1.96]), AD (2.12 [1.88-2.39])”

   Humansper-unit increment in brain age gap z-scoreplasman = 45,113

   PROTEOMIC BRAIN AGE GAP, DEMENTIA RISK, AND BRAIN VOLUME MEASUREMENTS · GSA 2024 abstract · 31 Dec 2024

Alzheimer's disease →

1. Proteomic brain age gap raises the risk of all-cause dementia in humans (HR 1.82, 95% CI 1.69-1.96).

   “Per-unit increment in the brain age gap z-score was associated with significantly elevated risks of all-cause dementia (hazard ratio [95% confidence interval], 1.82 [1.69-1.96])”

   Humansper-unit increment in brain age gap z-scoreplasman = 45,113

   PROTEOMIC BRAIN AGE GAP, DEMENTIA RISK, AND BRAIN VOLUME MEASUREMENTS · GSA 2024 abstract · 31 Dec 2024

All-cause dementia →