Heart proteomic age

1. Heart proteomic age raises the risk of coronary heart disease in humans (HR 1.16 (95% CI 1.07-1.26) per 5-year-higher age gap).

   “and 1.16 [1.07-1.26], respectively”

   Humansheartn = 11,757

   Biological organ ages associate with risk of chronic diseases in a community-based population

   JCI insight·8 Dec 2025

More on Coronary heart disease

1. Heart proteomic age is associated with heart failure severity in humans (OR = 1.12, 95% CI 1.03 to 1.23).

   “Heart OAA was significantly associated with advanced HF (Stage C/D) in both sexes (OR = 1.12, 95% CI 1.03 to 1.23 in women; OR = 1.18, 95% CI 1.05 to 1.32 in men)”

   HumansHELPFul cohortfemales

   Proteome organ aging and cardiometabolic risk in a population at risk for heart failure

   Cardiovascular diabetology·12 Nov 2025